Syracuse combines university influence, Upstate NY character, and distinct Italian-American heritage in this historic Central New York city.
These five pizzerias represent Syracuse’s best in 2025.
1. Twin Trees Restaurant
A Syracuse institution since 1957, Twin Trees defines the distinctive local style with medium-thick rectangular pies cut in strips rather than triangular slices.
Their slightly sweet sauce and edge-to-edge toppings create a uniquely Syracuse experience that generations of locals consider definitive.
The “Original” features their perfect balance of sausage, peppers, and cheese on this exceptional foundation.
2. Varsity Pizza
Serving Syracuse University students and faculty since 1926, Varsity creates thin-crust pies that have fueled Orange fans through generations of championships and campus traditions.
Their classic slices maintain the perfect fold and balance that define East Coast pizza.
The Marshall Street location buzzes with university energy, while historic photographs documenting decades of campus life create a museum-like connection to Syracuse history.
3. Apizza Regionale
Bringing authentic Neapolitan techniques and farm-to-table philosophy to Syracuse, Apizza Regionale creates wood-fired pies with local sourcing and Italian tradition.
Their naturally leavened dough develops complex flavor through extended fermentation, while seasonal ingredients from Central New York farms create distinctive combinations.
The renovated historic building in downtown Syracuse contributes to urban revitalization while honoring architectural heritage.
4. Paladino’s Pizza
This neighborhood favorite delivers classic Syracuse-style pizza with rectangular cut and balanced toppings at family-friendly prices.
The “North Side Special” celebrates the historically Italian neighborhood with traditional combinations on their excellent crust.
The warm, unpretentious atmosphere welcomes diverse customers, from working families to university students seeking authentic local flavor.
5. Blaze Pizza
This modern chain’s Syracuse location has distinguished itself by combining fast-casual efficiency with quality ingredients and consistent execution.
Their build-your-own model allows unlimited toppings on thin, crispy crusts prepared in just 180 seconds.
Beyond customization, signature combinations like the “Syracuse Orange” with local touches satisfy those seeking curated experiences.
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