5 Best Pizza Places in Harrisburg, Pennsylvania to Try

Harrisburg’s pizza scene is a delicious reflection of Central Pennsylvania’s cozy neighborhoods and close-knit community.

From classic Italian family restaurants to urban pizzerias and modern creative spots, Harrisburg offers everything from old-school square pies to handcrafted wood-fired marvels.

Here are the five best pizza places in Harrisburg for 2025, celebrated for their signature flavors, fan devotion, and homey vibes.

1. Palermo Pizza & Restaurant

A true Harrisburg institution, Palermo Pizza delivers consistently delicious pies with hearty toppings and a perfectly chewy crust.

Their classic New York–style pizza is a neighborhood favorite, but locals also rave about Palermo’s white pizza and robust “Special” loaded with meats and veggies.

Casual, welcoming, and always reliable for dine-in, takeout, or delivery.

2. Naples Pizza

Known for giant slices, classic Italian subs, and quick counter service, Naples Pizza is a downtown staple.

The pies strike the right balance—thin but substantial crust, zingy sauce, and gooey cheese.

The menu includes specialty toppings and old-world comfort food, making it the ideal lunch stop or late-night bite in the heart of the city.

3. Pizza Grille

Blending urban bistro energy with creative toppings and a crispy thin crust, Pizza Grille has won over critics and families alike.

Their gourmet pies—think BBQ chicken, shrimp and feta, or margherita with fresh basil—pair perfectly with salads and craft cocktails.

The sleek dining room and outdoor patio make this spot as appealing for date night as for after-work crowds.

4. Home 231

While best known for farm-to-table American fare, Home 231’s rotating menu always includes a standout artisanal pizza.

Expect tender, wood-fired crusts topped with locally sourced ingredients, seasonal produce, and culinary creativity.

With an intimate setting in historic Midtown, it’s a must for foodies seeking something unique, upscale, and truly Harrisburg.

5. Jo-Jo’s Pizza & Restaurant

A family-run favorite with multiple area locations, Jo-Jo’s is beloved for its jumbo slices, thick Sicilian pies, and robust Italian-American comfort food.

Their “Jo-Jo’s Special” piles on sausage, pepperoni, mushrooms, and bell peppers—a true party pie—and the friendly service keeps regulars coming back. Takeout and delivery are top-notch, making Jo-Jo’s a go-to for any occasion.